Four prebiotic ingredients—Bimuno GOS by Clasado Biosciences [2], ButyraGen from NutriScience [3], Wellbiome by Optibiotix [4], and Raia-KFS from Orgenetics [5]—are part of a list of industry innovators. Rounding out that list are the postbiotics RHT3201 by Nutralliance [6] and LBiome from Stratum Nutrition [7], and the probiotic blends BPL1 HT by ADM [8] and SynBalance DefensePlus from SynBalance [9].
Here, we give you one of each of the prebiotics, postbiotics and probiotic blends. For the complete list, download the latest free Natural Products Insider digital magazine [10].
1. Clasado Biosciences
Bimuno GOS
What it is: Galactooligosaccharide (GOS) with 20 human clinicals on gut, immune support and cognitive health, including symptom relief of irritable bowel syndrome (IBS), inflammation biomarkers, increasing activity of natural killer (NK) cells and supporting the gut-brain axis.
Emblematic science: A study [11] found Bimuno GOS was superior to a traditional GOS in increasing bifidobacterial species and at a lower dose. A 2015 double-blind, placebo-controlled study [12] for 10 weeks using 5.5 g/d on 40 elderly subjects age 65-80 found positive influence on gut microbiota, immune parameters and metabonomics, suggesting use in positively affecting the microbiota and markers of immune function associated with aging.
Innovation: Targeted prebiotic with a proprietary composition of GOS has a unique blend of qualities that feeds and stimulates the growth of bifidobacteria.
[To read about the NutriScience ButyraGen, the OptiBiotix ButyraGen and the Orgenetics ButyraGen, download the free NPI digital magazine [10].]
2. Nutralliance
RHT3201
What it is: Scientifically and clinically validated postbiotic ingredient with an anti-allergy effect that has a New Dietary Ingredient (NDI) filing and Korean FDA functional ingredient approval.
Emblematic science: An optimal heat-treated temperature was established on L. rhamnosus IDCC 3291 isolated from Korean infants fed breast milk, then the bacterial cells enumerated for maximum effect, with positive results seen in a 12-week study [13] of children ages 1-12 with moderate atopic dermatitis. The randomized, double-blind, placebo-controlled study found no differences in safety parameters between the two groups.
Innovation: Standardized postbiotic ingredient made with patented technology and certified under various regulatory agencies, including FDA and KFDA.
Market potential: Useful in supplements, beverages and foods.
[To read about the Stratum Nutrition LBiome postbiotic, download the free NPI digital magazine [10].]
3. ADM
BPL1 HT
What it is: B. animalis subsp. lactis CECT 8145 and its heat-treated counterpart BPL1 HT with particular efficacy for weight management applications.
Emblematic science: A study [14] showed impact on visceral fat reduction, a healthy waist circumference and metabolic health pathways.
Innovation: Its postbiotic form is capable of nearly limitless formulation applications because of the BPL1 strain’s innate robustness, and formulators don’t have to make adaptations for live colony-forming units (CFUs) as compared to traditional probiotics.
Market potential: Because it undergoes a heat-treated process and contains nonviable microorganisms, it can withstand harsh formulation environments like high heat in baked goods and snacks or pasteurization in dairy products or energy drinks.
[To read about the SynBalance DefensePlus postbiotic, download the free NPI digital magazine [10].]